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IFC
Gnepp's Diagnostic Surgical Pathology of the Head and Neck
Gnepp's Diagnostic Surgical Pathology of the Head and Neck
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CONTENTS
PREFACE
ACKNOWLEDGMENTS
LIST OF CONTRIBUTORS
ABBREVIATIONS USED IN TEXT
1
Precursor Lesions for Squamous Carcinoma in the Upper Aerodigestive Tract
General Introduction
Oral Cavity
INTRODUCTION
NORMAL ORAL ANATOMY
ORAL POTENTIALLY MALIGNANT DISORDERS
Erythroplakia, Leukoplakia, and Speckled Leukoplakia
Proliferative Verrucous Leukoplakia
Verrucous Hyperplasia Oral Submucous Fibrosis and Changes in Betel Chewers
Lichen Planus
Discoid Lupus Erythematosus
Human Papillomavirus and Oral Epithelial Dysplasia
Dyskeratosis Congenita
Fanconi Anemia
Sideropenic Dysphagia
Syphilis
Palatal Changes in Reverse Smokers
Cheilitis Glandularis
Other Conditions
PROGRESSION AND TRANSFORMATION OF ORAL DYSPLASTIC LESIONS
Clinical Adjuncts to Diagnosis. Over the past two decades, there has been a dramatic increase in the development of potential or..
Biopsy Sampling and Handling
Features of Dysplasia
Grading Dysplasia Clinical-Histological Correlations
Detection of Early Invasion
Intraoperative Frozen-Section Assessment of Dysplasia
PREDICTIVE BIOMARKERS
TREATMENT OF OPMD AND ORAL DYSPLASIA
Active Surveillance
Surgical Treatment
Chemoprevention
Oropharynx
INTRODUCTION
ANATOMY AND HISTOLOGY
CLINICAL AND PATHOLOGICAL FEATURES
Nasopharynx
INTRODUCTION
ANATOMY AND HISTOLOGY
CLINICAL AND EPIDEMIOLOGICAL ASPECTS
PATHOLOGIC FEATURES AND DIFFERENTIAL DIAGNOSIS
GENETICS
Nasal Cavity and Sinuses
ANATOMY AND HISTOLOGY CLINICAL, EPIDEMIOLOGICAL, PATHOLOGICAL, AND GENETIC ASPECTS
Larynx and Hypopharynx
INTRODUCTION
ANATOMY AND HISTOLOGY
EPIDEMIOLOGY
ETIOLOGY
CLINICAL FEATURES
PATHOLOGIC FEATURES
INTRAOPERATIVE FROZEN SECTIONS
DIFFERENTIAL DIAGNOSIS
GENETICS
Introduction
Chromosomal Changes
Tumor Suppressor Gene Inactivation and Allelic Loss
Microsatellite Instability
Protooncogene Activation
Telomerase Reactivation
Epigenetics
Expression Profile Data
TREATMENT AND PROGNOSIS
2
Squamous Cell Carcinoma of the Upper Aerodigestive System
Introduction Introduction
General Comments
EPIDEMIOLOGY AND RISK FACTORS
Lip
Oral Cavity and Pharynx
Larynx
Sinonasal Cavities
Nasopharynx
Trachea
Analytic Epidemiology
Syndromes
MULTIPLE PRIMARY TUMORS
LOCAL AND DISTANT METASTASIS
Site-Specific Features
NASOPHARYNX
SINONASAL CAVITIES
LARYNX AND HYPOPHARYNX
Hypopharynx
Larynx
TRACHEA
ORAL CAVITY/OROPHARYNX
Tongue
Floor of the Mouth
Cheek
Alveolar Ridge
Retromolar Trigone
Hard Palate
OROPHARYNX
Base of the Tongue
Tonsillar Area and Soft Palate
Pharyngeal Wall