Cell Biology
- New Delhi Scientific International Pvt. Ltd 2022
- xiv, 513p.
1. Introduction to Cell Biology Introduction. Discovery of Cell Emergence of Modern Cell Biology. Cytology and Other Biological Sciences.
2. Organization of Cell. Introduction. History of Cell Cell Theory. Cell as a Self-Contained or Autonomous Body. Cellular Totipotency. Diversity in Size and Shape of Cells Types of Cells. 1. Prokaryotic Cells or Prokaryons Bacterial Cell, Cyanobacteria, Pleuropneumonia-like Organism. 2. Eukaryotic Cells or Eukaryons. Viruses : An Exception to Cell Structure. Viroids and Prions.
3. Chemistry of Living Matter—The Protoplasm. Protoplasm Cellular Pool. Biomolecules. I. Water. II. Inorganic Substances. III. Organic Molecules. 1. Carbohydrates. 2. Lipids. 3. Proteins. 4. Nucleic Acids. Watson and Crick’s Model of DNA (Molecular Structure of DNA). 5. Ribonucleic Acid (RNA). 6. Enzymes. Holoenzymes and Apoenzymes. Isozymes. 7. Vitamins. Regulatory Substances. Prostaglandins.
4. Cell Membrane. Biomembranes. Ultrastructure of Biomembranes. Significance of Biomembranes. Plasma Membrane. Ultrastructure. Chemical Composition. Evolution of Molecular Structure (Models of Plasma Membrane). Fluid Mosaic Model of Plasma Membrane. Membrane Asymmetry. Fluidity of Plasma Membrane. Cell Coat Biogenesis or Origin of Plasma Membrane. Functions of Plasma Membrane
5. Membrane Functions: Cell Adhesion and Cell Junctions. Cell Adhesion Molecules (CAMS) Cadherins, Integrins, Selectins Immunoglobulins Cell Junctions. Desmosomes or Macula Adherens. Belt Desomosomes or Zonula Adherens, Tight Junctions or Zonula Occuludens Gap Junctions (Nexus).
6. Transport Across Cell Membrane. Permeability and transport Transport Across Plasma Membrane. 1. Osmosis. 2. Passive Transport. Diffusion, Facilitated Diffusion. 3. Active Transport. 4. Transport of Ions 5. Transport of Large Molecules viii Contents
8. Cytoskeleton. Cytoskeleton. 1. Microfilaments. 2. Intermediate Filaments (IFs). 3. Microtubules. Motor Proteins or Molecular Motors.
9. Cell Signaling Steps of Cell Signaling. Significance of Cell Signaling Modes of Cell Signaling. Signaling Molecules Cell Surface Receptors Pathways of Intracellular Signal Transduction
10. Endomembrane System Endoplasmic Reticulum (ER) Annulate Lamellae. Inter-relations of the Cell Membranes. Microsomes.
11. Golgi Complex. History. Occurrence of Golgi Complex. Morphology of Golgi Complex. Membrane Flow in Golgi Complex. Membrane Recycling. Origin of Golgi Complex. Functions of Golgi Complex.
12. Microbodies : Lysosomes, Peroxisomes and Glyoxisomes. Lysosomes (The Suicide Bags of Cell). Peroxisomes. Glyoxysomes Lysosomes in Plants Spherosomes, Aleurone Grains, Vacuoles Contents ix
13. Vesicular Transport. Vesicular Transport. Endocytic and Secretory Pathways. Protein Sorting and Vesicular Traffic from ER to Golgi. Transport from Trans Golgi Network Types of Secretory Pathways.
14. Cellular Energy Transections. Cell and Energy. Exergonic and Endergonic Reactions. Concept of Free Energy. Energy Flow and Laws of Thermodynamics Energy Transformation in Living Systems. Adensosine Triphosphate.
15. Mitochondria Ultrastructure of Mitochondria. Electron Transport System (ETS) or Respiratory Chain Mitochondrial DNA Mitochondrial RNA. Ribosomes and Protein Synthesis in Mitochondria Semiautonomous Nature of Mictochondria (Symbiont Hypothesis). Biogenesis of Mitochondria. Degeneration of Mitochondria. Functions of Mitochondria
16. Cellular Respiration and Energy Production. Cellular Respiration Respiratory Substrate. Types of Cellular Respiration. Mechanism of Respiration. Oxidation of Extramitochondrial NADH. Some Other Pathways of Glucose Metabolism. Differences Between EMP, PPP and ED Pathways. Glyoxylate Cycle.
17. Plastids Classification of Plastids. Origin and Development of Plastids. Functions of Plastids. Chloroplasts. The Photosynthetic Apparatus. Mechanism of Photosynthesis. Necessity of Two Photosystems. Other Pathways of Fixation Chloroplasts as Semiautonomous Organoids. Symbiotic Origin of Chloroplasts.
18. Ribosomes. Ultrastructure of Ribosomes. Mitochondrial and Chloroplast Ribosomes, Ribosomal Proteins Biogenesis of Ribosomes.
19. Centriole and Cell Centre. Ultrastructure. Associated Structures of Centrioles. Chemical Composition of Centrioles Functions
21. Interphase Nucleus. Structure of Interphase Nucleus 1. Nuclear Envelope. 2. Nucleoplasm or Nuclear Matrix 3. Nucleolus. 4. Chromatin or Nuclear Recticulum. Euchromatin and Heterochromatin.
22. Chromosomes. What are Chromosomes?. Viral Chromosomes Prokaryotic Genome. Mitochondrial Chromosome. ukaryotic Chromosomes. Different Regions Recognized in Chromosomes Molecular Organisation of Chromosomes. Special Types of Chromosomes: 1. Lampbrush Chromosomes. 2. Polytene Chromosomes. Physiology of Chromosomes.
23. Cell Division. Cell Cycle. Check Points in Cell Cycle. Maturation Promoting Factor (MPF). Cell Division. 1. Amitosis. 2. Mitosis. Energetics of Cell Division. Meiosis I. Heterotypic Division (Reduction Division) II. Homeotypic Division Salient Features of Meiosis Synapsis in Chromosomes.
24. Cell Growth, Cellular Ageing or Senescence and Cell Death Cell Growth. Growth in Unicellular Organisms. Growth in Multicellular Organisms. Mechanism of Cell Growth. Cell Types Based on Different Growth Patterns. Cellular Ageing or Senescence. Pace of Cellular Ageing. Changes During Ageing. Theories to Explain Cell Senescence. Regulation of Size of Cell
25. Cancer What is Cancer?. Types of Cancers. Characteristics of Malignant Tumours. Characteristics of Cancer Cells. Causes of Carcinogenesis. Theories of Caroinogenesis
26. Microscopy Tools to Study Biology Microscopy. Light Microscope. Phase Constrast Microscope. Differential Interference Microscopy Polarisation Microscope Ultraviolet Microscope. Fluorescent Microscopy. Spectrophotometry. Electron Microscope. Principle Types Working of TEM Working of SEM Preparation of Material for Electron Microscope X-Ray Diffraction Microscopy : Special Features.
27. Cytochemical Techniques. Cytological Study of Preserved Cells Fixation. Embedding. Sectioning. Staining. Morphological and Cytochemical Stains.
28. Cell Separation and Cell Fractionation by Centrifugation Flow Cytometry. Cell Fractionation Tissue Homogenisation. Centrifugation. Density Gradient Centrifugation. Types of Centrifugation. Ultracentrifugation. Centrifugal Elutriation. Flow Cytometry.
29. Molecular Separation by Chromatography. Chromatography. Principle of Chromatography. Applications of Chromatography. Types of Chromatography. Column Chromatography. Partition Chromatography Paper Chromatography. Gas Chromatography. Thin Layer Chromatography. Gel Filtration Chromatography. Ion Exchange Chromatography